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Katherine Heigl is taking a five-episode hiatus from the ABC drama to go shoot the Greg Berlanti-directed romantic comedy "Life as We Know It". Heigl's absence will be explained on screen, although it's not clear what prompts Izzie to take off. (Marital trouble with Alex? A trip home to see mom? A Denny sighting in the Caribbean?)

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The show recently announced that it was adding three new doctors to its rotation: Nora Zehetner, Robert Baker, and Jesse Williams are joining the cast as recurring residents/ medical professionals.