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"'House is off the Vicodin, but he's also sort of being an ass or child or both,' [executive producer Katie] Jacobs says. The big question, which follows him back to Princeton-Plainsboro, is whether he can make deeper changes. 'Could it be a different House?' she asks. If House went into that hospital with a big, fat hole in his center, he doesn't come out full. Maybe one piece is there that wasn't there before."

Wilson (Robert Sean Leonard), the oncologist who has been House's anchor, faces his own struggles after dealing for years 'with patients he can't cure'.

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