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Izzie and Alex will deal on a major blow at the end of next week’s episode [Invasion] which is also quoted as the best of the season. “BTW, even though I knew Katherine Heigl’s mini-hiatus was coming, Izzie’s exit was no less powerful or emotional. And man, Heigl knocks it out of the park.” – M. Ausiello

When asked when will Ellen Pompeo’s maternity leave from Grey’s Anatomy kick in on screen, Ausiello says that unlike Izzie, Meredith isn’t going anywhere — although we’ll begin to see less of her (literally and figuratively) after this week’s episode.