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On the eve of Thanksgiving, House and the team take on the case of James Sidas (guest star Esteban Powell), an exceptionally brilliant physicist and author who traded his successful career for a job as a courier. For the ailing patient, intelligence is a miserable burden that has prompted depression and addiction, and this, coupled with a myriad of strange symptoms, nearly stumps the team. Meanwhile the doctors at Princeton Plainboro wrestle with strained personal relationships.

[Episode Description from House-MD.pl]