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After a wild night out, a teenage girl (guest star Anna Attanasio) is brought to Princeton Plainsboro with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill. As her condition worsens, she becomes unable to distinguish fact from fiction. Meanwhile, Cuddy, Wilson (Robert Sean Leonard) and House spend a weekend away from the hospital to attend a medical conference, but things don’t go as planned when House’s private investigator, Lucas (guest star Michael Weston), returns.

[Episode Description from House MD Dot Com]